In addition to high mortality, the impact of violence on morbidity was substantial, as observed in other settings [ 9], while at the same time access to essential health services was limited by insecurity or cost.
Although condom knowledge was high, and use increased substantially, overall condom distribution was of the order of 4 6 million condoms/year; an amount of condoms that could not have influenced overall reductions in HIV prevalence as substantial as observed (Moodie et al., 1991; USAID, 2003).
It is unlikely, however, that such biases could lead to effects as substantial and specific as observed in our study.
This observation is in agreement with the [Ca2+]o-dependent SOICR activity described above, indicating that a substantial SOICR activity, as observed with HEK293 cells expressing the former RyR2 variants, is accompanied with a reduced steady-state Ca2+ loading of the internal store and a reduced threshold for SOICR.
Although the decrease in phosphorylation of the p21 S116A) mutant was not as substantial as that observed with the p21 S146A) mutant, it was still reproducibly less phosphorylated by RSK2 than was the GST-p21 wild-type protein.
In the present study, we confirmed that relevant pulmonary hypertension may be missed by the miniaturized system (Table 1), especially in the absence of significant right ventricular enlargement as observed in a substantial proportion of acute cor pulmonales [ 17].
In P. berghei, simultaneous disruption of the two SERA genes does not affect parasite growth [39]; however, substantial expression of these two genes, as observed in this study, cannot rule out their importance in rodent parasites.
Thyroid-stimulating hormone elevation can be quite substantial even within one sunitinib cycle, as observed, for instance, in one patient, from a normal 0.19 to a high of 78.63 mIU l−1.
Moreover, the very high level of catheter-site colonization, as observed for a substantial number of patients in our study, would have caused confluent growth when using the contact plate method and would thus have impeded quantification of the colonizing microorganisms.
However, the equation proposed by Flesch-Janys et al. (1996) may be problematic for ages > 60 years because very small variations in the elimination rate could lead to substantial divergence in half-life length, as observed in the case of 1,2,3,7,8-PeCDD.
As observed for the 2-AB method a shorter gradient resulted in substantial loss of resolution.
