However, 18S rRNA expression is monitored primarily to double check for substantial anomalies in mRNA quantification when positive results are found, rather than as a precise means of normalization for results which appear consistent.
Substantial negative anomalies occurred in 1984 and 1990 , 1993and 2002, when the calculated indices were between −1.5 and −1.6, which signify relatively dry years.
Conversely, substantial positive anomalies occurred in 1989, 1994, 2007, 2008 and 2009 with SAI between +1.5 and +2.2, and the highest index occurred in 2009.
Toon reported in Science in 2007 that even a "small-scale" conflict involving 100 weapons could kill 21 million people and release enough smoke to cause "substantial global-scale climate anomalies" lasting years.
Type 1: Samples 8 and 11 (Na–HCO3 type) have substantial negative, shale-normalized Ce anomalies (Ce/Ce* = 0.25 and 0.2, respectively), low positive Eu anomalies (Eu/Eu* = 0.0034 and 0.0045, respectively) and low positive Gd anomalies (Gd/Gd* = 0.86 and 0.67, respectively).
In a substantial group of patients with opening anomaly, there is a bulbar stenosis occasionally defined as duodenal deformity which in fact can be better described as apical stenosis.
Also relevant is the substantial literature on the role of anomalies, discrepant events, and cognitive dissonance in stimulating learning.
In the Atlantis's 2000 mission, according to the NASA in-flight anomaly report, the much smaller gap caused a "substantial flow path" of plasma past the protective leading edge panels.
If this position is artifactual (which is a distinct possibility), the anomaly in the evolution of this branch is so substantial that its position is insensitive to the details of the evolutionary model used in phylogeny reconstruction.
This substantial local CN expression of 22q11 genes, as well as E9.5 hindbrain anomalies, suggests that CN differentiation might be altered in the LgDel mouse at E10.5.
