Sentence examples for substantial and extensive from inspiring English sources

The cleavage was modest at 2 days after injection and more substantial and extensive at 8 and 16 days.

Most of the isolates show substantial and extensive drug resistance, providing major therapeutic challenges for clinicians, especially if patients are treated as they would be for drug susceptible tuberculosis.

The loss of VAMP1 became more substantial and extensive (2.5 ± 0.2 mm, n = 5) eight days after injection (Figs.  1b, c, 3) and started to recover by 16 days (Fig.  3).

This type of building is usually considered unsuitable for heat pumps, unless substantial insulation work and extensive replacement of radiators are undertaken.

These data indicate that the evolution of these two chromosomes has involved substantial gene duplication and extensive lateral gene transfer events (preferentially with related organisms, i.e., β-proteobacteria).

Comparative mapping between the grass carp and other model organisms revealed that substantial macrosynteny relationship and extensive colinearity existed between grass carp and zebrafish.

Substantial sweat losses and extensive related body water and electrolyte deficits are not uncommon, 1 5 as is a level of thermal strain that considerably challenges a player's physiology, perception of effort and on-court well-being and performance.

BLAST searches of sequences of mapped markers of grass carp against the whole genome sequence of zebrafish revealed substantial macrosynteny relationship and extensive colinearity of markers between grass carp and zebrafish [ 12].

We evaluated long-term particle mass exposure in relation to three measures of arterial stiffness measured at one point in time in a large, multiethnic sample with a substantial age range and extensive information on covariates.

Competitive tennis in the heat can prompt substantial sweat losses and extensive consequent body water and electrolyte deficits, as well as a level of thermal strain that considerably challenges a player's physiology, perception of effort, and on-court well-being and performance.

This study documents that the rescue and recovery and cleanup efforts carried out by the workers at the World Trade Center are associated with substantial chronic psychological morbidity and extensive impairment of social functioning.