60 Starting and maintaining treatment over the course of 6 12 months can result in substantial costs that are intangible and difficult to measure.
With refugee flows predicted to be massive and widespread reconstruction requirements a certainty even in the unexpected event of a quick US-Iraqi success, the next president may soon face substantial and difficult decisions about Mosul in the battle's aftermath.
10 The economic burden associated with treating RCC is substantial, but difficult to characterize, as evidenced by the wide range of cost estimates found across studies.
The 3'-UTRs of the atpH genes show substantial variation and were difficult to align.
While not a novel technology, fracking has taken off in the USA and Canada in regions with substantial yet traditionally difficult to harvest shale gas [1].
Although the impact of patients at OMERACT has been substantial, it is difficult to summarise how the experiential knowledge of partners is actually utilised during the OMERACT breakout sessions.
Scientific papers typically now bring together large collaborations and substantial data; it's difficult to stitch all these together coherently, and the trend is toward increased complexity and collaborations.
Supervised training, however, requires specific and substantial resources and may be difficult to apply in a clinical context.
Despite these advances, however, the practical application of measurement and innovation to enhance quality in practice requires substantial motivation and resources, and may be difficult to implement and maintain, particularly in small office settings.
