Sentence examples for substantial and difficult from inspiring English sources

With refugee flows predicted to be massive and widespread reconstruction requirements a certainty even in the unexpected event of a quick US-Iraqi success, the next president may soon face substantial and difficult decisions about Mosul in the battle's aftermath.

First, as explained in the previous section, a substantial and difficult to estimate number of true pseudogene alleles were excluded from the analysis because they could not be reliably distinguished from PCR chimaeras on the level of the full dataset.

Regarding non-endemic vector-borne diseases, respondents noted that the impacts could be substantial and difficult to adapt to, and referred to public perception ('fright factors' and public unrest).

"But because of long standing wage and other differences what we will see is a lot more seniors forced to make substantial sacrifices and difficult choices".

The first two years of work with tri-borough colleagues in Kensington & Chelsea and Hammersmith & Fulham show that substantial savings are achievable and difficult problems can be tackled by working in partnership with other local authorities.

60 Starting and maintaining treatment over the course of 6 12 months can result in substantial costs that are intangible and difficult to measure.

We therefore sought to test one component of mutation rate variation that is both substantial and likely to be difficult to predict, the so-called cryptic variation in the mutation rate (Hodgkinson et al. 2009; Johnson and Hellmann 2011).

However, a strong genetic by environment (GxE) interaction and relatively low heritability of Al tolerance in maize complicates selection and has made substantial progress difficult [3], [5], [24].

School for children, and jobs for adults, were signifiers of living 'normally'[ 24], providing purposeful activity, an opportunity for social interaction, a sense of achievement, self-value and social recognition, income and social security[ 7, 29] However, needs stemming from work and education were substantial, posing difficult choices.

Evan Rytlewski of The A.V. Club wrote that "without playing into cheap 'tortured by fame' tropes, she's made an emotional album that's dense and substantial but never difficult or self-important".

This has made the job of substantial change difficult, at a time of growing fears in Italy that it is falling behind the rest of Europe.