However, a very large number of permutations and a substantial amount of computation time are required to accurately calculate the P-value to test for differential expression.
The notion that integrating a substantial amount of computation into a traditional biology class could negatively affect a student's ability to apply mathematical and statistical results to biological concepts is not without basis.
Decoding large blocks requires significant amounts of computation and memory.
On the other hand, BOAT and RazerS required significant amounts of computation time.
We observed that SSAHA2, Segemehl, and PASS required significant amounts of computation time; in contrast to Bowtie, SOAP2, RazerS, and GASSST relatively showed high computation speed.
"We were losing substantial amounts of money.
One is the learning of substantial amounts of technical information.
Many of the larger procellariids consume substantial amounts of squid.
Paper products take substantial amounts of energy to make.
They [the homes] are losing substantial amounts of money".
