Sentence examples for substantial amount of sequence from inspiring English sources
To obtain good predictions from computational methods, a substantial amount of sequence analysis is necessary that takes into account the idiosyncrasies of the gene of interest and thus cannot be automated.
This is due to the fact that, within each species, the splice variants share a substantial amount of sequence identity.
The other two methods assigned a substantial amount of sequence data incorrectly to bins at the family level or below.
We sought to improve this situation using the substantial amount of sequence data now available from across eukaryotes, particularly from animals (Metazoa), green plants (Viridiplantae) and Fungi.
Although we demonstrate that a purely structure-based homology search is feasible in principle, it is unlikely to outperform tools such as Infernal in most application scenarios, where a substantial amount of sequence information is typically available.
First, under the hypothesis that a substantial amount of sequence exists in the ChrUn for the missing microchromosomes and that these microchromosomes could correspond to regions of human chromosomes of substantial size by conservation of synteny, we selected supercontigs from the chrUn that cluster in specific regions of human chromosomes by comparative genomics.
Mutation discovery is challenging as it requires a substantial amount of sequencing and analysis to detect very rare changes and distinguish them from noise.
Assembly of sequences from metagenomic libraries can result in good draft or even complete genomes when the target species shows little intraspecies variation, but this usually requires a substantial amount of sequencing.
Given that the full-length MaSp1 gene copy (locus 1) is a ∼10 kb single exon gene, cross-hybridization could occur among gene copies due to the substantial amounts of sequence conservation observed among the three known loci [11], [25].
For example, a recent investigation into DNA variants causing X-linked mental retardation included substantial amounts of sequence information on the coding regions of X-linked genes [Tarpey et al., 2009].
As a result of phage insertion the genome gains a substantial amount of foreign sequence, much of which encodes phage structural proteins.
