"substantial alternation" is a correct and usable phrase in written English.
You can use it to describe an extensive change. For example: "This policy underwent a substantial alternation and now has much stricter regulations."
In some reports [10, 33 40], piezofluorochromic property of AIE materials was suggested to be resulted from the substantial alternation of π-π overlap, the change of intermolecular packing modes or the transformation from amorphous state to crystalline state.
Substantial alternation by mutation of phenotypes governed by QTLs has been reported in other plants as well.
Substantial alternation of lipid metabolism has been shown in patients with acute CD associated with metabolic disturbances [ 38].
We have employed conservative priors (uniform, Jeffreys, Gaussian) that make an analytical treatment tractable but in some cases more information could warrant a different choice of prior that might require substantial alternations to our approach to handle the numerics of marginalisation.
Had the increasing effect on position bias been more substantial, the alternation rate would have been decreased as a logical consequence.
His fears for the independence of his crown were allayed by a number of special privileges for Bavaria, although his demands for a substantial territorial increase and the alternation of the imperial title between Prussia and Bavaria remained unfulfilled.
Substantial portions of the bottom of shallow lakes can experience periodic alternation of exposure to hypolimnetic and epilimnetic water, and hypolimnetic water can be periodically exposed to the surface.
This makes it less likely that the substantial effects we see from substitution of single N-terminal residues on activity are due to alternation of the translocation process.
Substantial fractions of dopamine neurons (35 65%) are activated by conditioned aversive stimuli presented in random or blockwise alternation with reward predicting stimuli [ 34,36,37], which exceeds the frequency of activations to unpredicted primary aversive stimuli (<15%).
The HCC stage was characterized by substantial hypermethylation, and a similar degree of epigenetic change was also observed for NSCLC, suggesting that such alternations are commonly associated with various malignancies in the late stages of carcinogenesis.
I think it's a nice alternation.
