Sentence examples for substantial alterations in from inspiring English sources

By appropriate migrations of biochromes, an animal can achieve substantial alterations in colour or shade for varying periods of time.

We conclude that long-term moderate alcohol consumption is associated with substantial alterations in the rat striatal proteome, particularly with regard to dopaminergic signaling pathways.

The MSCs isolated from infants who later developed BPD demonstrated substantial alterations in the pathways controlling the differentiation towards myofibroblasts platelet-derived growth factor (PDGF)-receptor- α, β-catenin, and TGF β1—in vitro [5, 18].

In contrast, our current work with paclitaxel nanosuspension delivery shows substantial alterations in the pharmacokinetic properties of paclitaxel compared with the standard Cremophor EL formulation (Figures 3 and 4).

During this process, substantial alterations in the composition of maternal extracellular matrix play an important role by providing a prosperous medium for implantation as well as modulating trophoblast invasion leading to the formation of a functional placental unit.

Careful observation in different environments and lightings cannot resolve the question of the precise causes of the chameleon's changes of color but does yield surprising evidence that changes in temperature appear to effect substantial alterations in coloration.

Jerry Hewes, Mayville, New York   Research has shown that epigenetic changes can result in substantial alteration in when and how genes are expressed based on our interactions with our environment.

Post-biopsy mammography usually shows no substantial alteration in the target lesion with conventional 14-gauge needles.

Results measured by blood oxygenation level dependent (BOLD -MRI indicated that organs and tumors expressing c-MET levels showed more suBOLD -MRI alteratindicatedood oxygenathat levels than thorgansthout c-MET expression.

However, a substantial alteration in the differentiation potential of ADSCs from both early and late passages (3rd and 14th, respectively) was found when the cells were switched to osteogenic differentiation conditions.

As a result of 1990s UK local government reform, York regained unitary status and saw a substantial alteration in its borders, taking in parts of Selby and Harrogate districts, and about half the population of the Ryedale district.