Sentence examples for substantial aggravation from inspiring English sources

Moreover, inactivation of PD-1 in an animal model for inherited demyelination in the peripheral nervous system implicating T-lymphocytes [13] leads to a substantial aggravation of the primarily genetically-caused neuropathy [14].

Dihydrokainate alone caused a substantial aggravation of the clinical EAE course thereby demonstrating the need for sufficient glial glutamate uptake during an autoimmune inflammatory challenge and indirectly confirming the role of glutamate excitotoxicity in EAE pathogenesis.

"I had to put aside my substantial irritation and aggravation.

Nevertheless, still a substantial portion of the population experienced a significant aggravation of its water scarcity conditions, or a movement into water scarcity (Supplementary Figs 12 14), also when we only examine the impact of these two forms of HI. Figure 4: Regional and seasonal variation in the dominant driver of change in water availability.

Buying one can save significant aggravation.

However, the committee did find substantial evidence linking "single-envelope" CFLs those with the bare spiral tube showing to aggravation of chronic actinic dermatitis, solar urticaria, lupus erythematosus, and photosensitive eye conditions.

Her PA who was nothing but aggravation... regenerating aggravation... becoming more and more aggravating as she grew older.

PD-1 is critically involved in these processes: in the presence of PD-1 on CNS CD8+ cells, activation and proliferation is limited, whereas absence of PD-1 leads to substantial increase of CD8+ cells, a higher propensity to secrete proinflammatory cytokines, multiple clonal expansions and an aggravation of neural damage.

Aggravation can be assisted by amending the policies of Annex I countries, in consequence to allocate a substantial share of their procurement activities to Certified Emission Reductions from least developed countries.

Given the substantial incidence of MDR-TB in Uzbekistan, delay in diagnosis increases the risk of onward transmission through untreated patients leading to aggravation of the situation in the region.

Traffic usually produces aggravation.