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Intrinsic fluorescence study reveals that the concerned gemini surfactants have a substantial affinity for PSA at a pH well above its isoelectric point.
Here, we engineered a tandem repeat construct (SRC2) showing substantial affinity for α2,6-sialylated N-glycans (in the order of 10−6 M in Kd), almost comparable to a natural α2-6Sia-specific lectin from Sambucus sieboldiana (SSA).
These studies found that Diva does not show "substantial affinity" for any BH3-derived peptide, including Bak and Harakiri.
Fabp3 is expressed in mature neurons in the dentate gyrus (our unpublished results) and reported to have a substantial affinity to ARA [31].
In 48 out of 100 RSC-DNA complexes only one extruding DNA end could be resolved, suggesting a substantial affinity for DNA ends.
However, it retains a substantial affinity for HP that might result from the stabilization of the complex through the collaboration between the conserved BBXB motif in the core of the chemokine and the remaining positive charges in the yet highly cationic C-ter domain.
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So unless you have a strong affinity for bitterballs — fried meatballs that are the buffalo wings of the Netherlands — you can't avoid spending a fairly substantial amount for decent meals.
The compounds 24 26 demonstrated substantial binding affinity and selectivity for A2AR as compared to SCH58261, a standard A2AR antagonist.
JB-788 was found to display substantial binding affinity for dopaminergic D2 receptors and, to a lesser extend to α1 adrenoreceptors.
Values for the mean equilibrium dissociation constant (KD = koff/kon) were low and similar for DEPN-8 (104 nM) and DPPC (89 nM), showing that both lipids had substantial molecular affinity for the chip-linked Mini-B monolayer (Table 2).
Calculated ADP ANT1 binding affinities were physiologically relevant and predicted substantial reductions in affinity upon acetylation of lysine 23.
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