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No substantial adverse events were reported.
Similar(58)
However, these devices present substantial risk for adverse events in the pediatric population.
The practitioners in this survey also reported a substantial number of adverse events associated with these medicines.
Almost three in ten patients reported on health safety issues, and patients as a group reported a substantial number of adverse events.
An examination of reports from healthcare professionals and patients in reporting systems is not sufficient to detect a substantial number of adverse events and thus cannot replace record review.
Neither a substantial systemic effect nor adverse events were observed.
The only treatment with a substantial highest level of adverse events was diacerheine.
Thirdly, a substantial proportion of the adverse events reported in these non-oncology phase I trials including the serious adverse events were judged unrelated to the study agent or study procedures.
Applying the model in a retrospective real-world scenario identified that the majority of the sample group of Australian patients aged 65 years and over with the target morbidity of the newly released COX-2-selective NSAID rofecoxib also suffered from a major morbidity excluded in the trials of that drug, indicating a substantial potential risk of adverse events amongst those patients.
Because these agents are so widely used, the potential scope of the health problem associated with NSAID related gastrointestinal adverse events is substantial.
There are also broader opportunity costs that may be substantial, such as suboptimal care, adverse events, loss of confidence by patients and referring general practitioners, and the potential for medical negligence claims.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com