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Thus per eLife policy not to require substantial additional experiments, we cannot consider the manuscript further at this time.
The reason for the negative decision is that very substantial additional experiments would be necessary to solidify the direct involvement of AMPK in the mechanism of ANGPTL4 regulation.
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Your revisions may require substantial changes to the experimental methodology, additional experiments, or analyzing the data over again in a different way.
A complete resubmission with substantial, robust, and (reasonably rapidly doable) additional experiments could make for an acceptable new submission, which will be examined to see if it retains novelty and whether the hypotheses stand up after examination of results from the experiments suggested.
However, the reviewers also expressed substantial concerns that should be addressed by additional experiments and/or by discussion before publication is recommended.
Both reviewers also raised some substantial concerns that will need to be addressed by additional experiments.
In addition, exploiting several symmetries – that often appear in feature terms databases – causes substantial additional savings.
This will be a substantial additional cost.
This file contains Supplementary Text, Discussion, additional experiments and references.
Additional experiments analyzed endoplasmic reticulum (ER) and mitochondrial stress responses.
J.J.H. and M.M. performed additional experiments on clinical samples.
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CEO of Professional Science Editing for Scientists @ prosciediting.com