Sentence examples for substantial additional effort from inspiring English sources

An assembly containing several uncaptured gaps can thus be quite challenging to finish, with other data required to deduce contig order and orientation; substantial additional effort is frequently involved during the finishing process, particularly in cases where the auxiliary data are weak or limited.

Compared to the assemblies generated with our optimized Phrap parameters, those generated using the 'repeat stringency' set at 99 or 'shatter greedy' were inferior with respect to the above measures, and would have required substantial additional effort to complete the finishing process.

However, in case of polyploid genomes substantial additional efforts are needed because hybridisation probes will usually not discriminate between (paleo)homoeologous sequences [ 8, 10, 19– 219.

Based on our data, we estimated that to achieve a reasonable completeness (≥ 75%) of the three quarters of most abundant (after normalization) transcripts, substantial additional sequencing effort may be needed, rendering the two-step strategy problematic.

Improving the power of such benthic surveys to detect trends would therefore require substantial additional time and effort to be invested in sample collection and analysis.

In an Ebola response road map outlined by WHO on August 28, the organization noted that the scale up in the virus outbreak and increasing preparedness efforts would "make a substantial additional demand on supplies of PPE".

As a whole, the dance literature supports substantial and wide-ranging benefits in both populations, but additional effort should be dedicated to well-designed comparative studies using standardized outcome measures to identify optimal treatment programs.

Level II geocoding provided additional data with little additional effort, whereas level III geocoding required substantial time and effort and might be more prone to errors in positional accuracy that is, locating an observation at the wrong parcel.

While this is a substantial reduction, it is still well above the fission industry norm, therefore, additional effort is needed to obtain further reductions.

No additional effort required.

This will be a substantial additional cost.