Sentence examples for substantial additional benefit from inspiring English sources

However, our model projections indicate that treatment with boceprevir-based regimens offer substantial additional benefit.

If found efficacious, such a treatment strategy has the advantage of being of population wide public health importance, and of substantial additional benefit across many disease states [ 6].

For both fitness costs, VYS provided substantial additional benefit (mean of 11%; highest value 16%) when the relative damage of CYS was >10% (Table S2).

A comparatively good CR rate, relatively short time to response, and the influence of VPA serum levels on response suggest that VPA provided substantial additional benefit.

Variable-mixture strategies provided a substantial additional benefit over constant-mixture strategies (i) when within-field infections predominated, regardless of the gene introduced (Fig. 1B, C), and (ii) when infections from the reservoir predominated, for R genes typically requiring only one mutation to be broken down (Fig. 3B).

It is also shown that by careful design it is possible to identify a strategy which costs no more than the do-minimum but which can generate substantial additional benefits.

However, given the very high rates of cardiovascular events in people aged over 80, substantial additional benefits might be expected.

We judged it likely both that the intervention was more complex than just sanitation and that substantial additional benefits were realized.

Considering the benefits of treatment, we found that treating tumours at earlier stages contributed greater health benefits overall than treatment at later stages and that population screening, while costly, would provide substantial additional benefits over clinical detection.

Vildagliptin significantly reduces both fasting and postprandial glucose levels over a dose range of 50 100 mg daily, and there are no substantial additional benefits of doses greater than 50 mg twice daily as monotherapy or in combination with metformin.

Combination treatment (cholesterol and BP lowering) for people whose risk of a cardiovascular event over the next 10 years is above 35% is also cost-effective, leading to substantial additional health benefits.