Sentence examples for substantial activity of from inspiring English sources

Moreover, substantial activity of one isoenzyme may compensate for the reduced activity of another one [ 34].

As expected, uridine completely prevented the activation of caspases-3/7 in the cells with normal ATF4 levels, but a substantial activity of caspase-3/7 (73–76% of the positive control) was observed in the cells with ATF4 knockdown.

Early clinical studies showed substantial activity of HDACi in relapsed and refractory cutaneous T-cell lymphoma (Mann et al, 2007) at doses that caused hyperacetylation of peripheral blood mononuclear cells.

A phase II trial of bevacizumab plus erlotinib revealed substantial activity of this combination in patients treated previously or patients who had not received treatment because of the presence of poor-prognostic features (Hainsworth et al, 2007).

Omlin et al (2013) report the anti-tumour activity of diethylstilbestrol (DS) and abiraterone (AA) in castration-resistant prostate cancer and suggest substantial activity of AA in DS pretreated patients.

Pinto et al (2007) were the first to study cetuximab in combination with irinotecan and 5-fluorouracil in this setting and recorded a response rate of 44% with a 95% CI ranging from 28 to 61%, thus indicating the substantial activity of this regimen.

A multipurpose CLEA with substantial activities of pectinase, xylanase and cellulase was prepared and characterized.

The abundant TE expression in meiocytes suggests substantial activities of TEs in meiosis.

Despite the substantial activities of all gluconeogenesis enzymes, gluconeogenesis itself is reported to proceed at very low rates in fetal hepatocytes and to be triggered by birth itself [ 48].

The nadir was generally between 2 and 8 h and substantial activity (to over 50% of pretreatment levels) had returned by 24 h after dosing.

By the early 3rd century, it had been rebuilt in stone and contained a number of buildings; excavations have uncovered evidence of substantial activity.