Sentence examples for substantial activation of from inspiring English sources

We found that anti-GD2 antibodies did not cause substantial activation of caspase-3: the level of activity of this effector caspase was 3 4 folds lower for anti-GD2-treated cells when compared to the EL-4 cells treated with staurosporine.

More direct studies of NF- κB activation revealed that Jurkat cells exposed to rhTRAIL did activate NF- κB. Figure 4 shows a substantial activation of NF- κB, 30 min following addition of rhTRAIL to the cells, although this activation was less pronounced than that caused by treatment with the strong NF- κB activator, TNF- α.

Surprisingly, the substantial activation of the phaG gene was observed.

Infact, in the downstream, substantial activation of caspase-3 was observed in supernatant-treated CD4+ T cells.

However, inhibition of miR-27a demonstrated more substantial activation of SPP1 expression in comparison with inhibition of miR-489.

With the exception of Alphavirus, the rest of RNA viruses tested here did not trigger a substantial activation of eIF2 kinases in infected cells.

Substantial activation was still maintained upon inversion of the fragment relative to the promoter (Fig. 5B).

This mechanism could explain how the brain circuits provide substantial background activation of NMDARs while maintaining a negligible ambient glutamate level in the extracellular space.

These data suggest that MVA85A vaccination does not induce substantial bystander activation of antigen-specific CD4 T cell populations.

Taken together, these considerations suggest that the lower ATP concentration would reduce allosteric inhibition, and the very much increased free AMP concentration in c4 tumours might lead to a substantial allosteric activation of PFK-1.

These data indicate that phosphorylation of SIN1 T86 results in a substantial and direct activation of mTORC2 kinase activity.