Sentence examples for substantial abnormality from inspiring English sources

Internal organs had a markedly soft consistency, but no other substantial abnormality was noted.

We found that disrupting peripheral circadian clocks using either dietary or genetic approaches results in substantial abnormalities of bile acid homeostasis.

Substantial abnormalities have also been reported for B10 and B1 cells in SLE.

Severe human infection with influenza viruses can result in substantial abnormalities of the lymphohematopoietic system, including lymphopenia, leukopenia, anemia and quantitative alterations of numerous serum analytes.

Additionally, we used a strict definition of a defective Ca2+ influx such that only substantial abnormalities were selected for further study.

More recently, in a study of Italian patients with Type 2 diabetes mellitus, substantial abnormalities in podocyte structure and density were found to occur during the early stages of diabetic nephropathy [ 13].

In addition, substantial abnormalities in pancreatic islet morphology and size have been described in Hmga1-knockout mice [ 13], indicating that decreased insulin secretion in this genotype may also depend on reduced beta-cell mass.

This observation is surprising because several structural and functional imaging studies of Alzheimer's disease reported substantial abnormalities in posterior brain regions in Alzheimer's disease relative to FTD (Varrone et al., 2002; Du et al., 2006).

These results are interesting as they show that either the range of prion diseases and associated pathology is still wider than previously thought or that substantial abnormalities of prion protein expression may be associated with brain lesions unconnected with classical prion diseases.

Bcrp-1 deficient mice lacked the SP in bone marrow yet had no substantial hematopoietic abnormalities [15].

Overall, these findings reflect substantial membrane abnormalities in the muscle of DNM2-S619L zebrafish.