Sentence examples for substantial abnormalities in from inspiring English sources

More recently, in a study of Italian patients with Type 2 diabetes mellitus, substantial abnormalities in podocyte structure and density were found to occur during the early stages of diabetic nephropathy [ 13].

In addition, substantial abnormalities in pancreatic islet morphology and size have been described in Hmga1-knockout mice [ 13], indicating that decreased insulin secretion in this genotype may also depend on reduced beta-cell mass.

This observation is surprising because several structural and functional imaging studies of Alzheimer's disease reported substantial abnormalities in posterior brain regions in Alzheimer's disease relative to FTD (Varrone et al., 2002; Du et al., 2006).

We found that disrupting peripheral circadian clocks using either dietary or genetic approaches results in substantial abnormalities of bile acid homeostasis.

Severe human infection with influenza viruses can result in substantial abnormalities of the lymphohematopoietic system, including lymphopenia, leukopenia, anemia and quantitative alterations of numerous serum analytes.

RD values were decreased by approximately 27.2% in gray matter but increased by approximately 20% in white matter.We found substantial abnormalities of FA, ADC, and RD values in an ex vivo canine Krabbe brain.

Substantial abnormalities have also been reported for B10 and B1 cells in SLE.

Overall, these findings reflect substantial membrane abnormalities in the muscle of DNM2-S619L zebrafish.

This prospective study provides further evidence of substantial chromosomal abnormalities in apparently normal blastocysts inside or outside of range of the most predictive morphokinetic parameters, including monosomy, trisomy, dual and complex aneuploidy [ 11, 12, 20, 60].

Internal organs had a markedly soft consistency, but no other substantial abnormality was noted.

There is therefore substantial concern about abnormalities in cloned humans.