Among the priority hazardous substances targeted by the WFD, short chain chlorinated paraffins C10 C13 (SCCPs), still represent an analytical challenge, because few laboratories are nowadays able to analyze them.
Here we review our recent discovery of novel gel-microemulsions (GM) as nontoxic, dual-function intravaginal spermicides, which can be used as delivery vehicles for lipophilic drug substances targeting sexually transmitted pathogens.
During a migraine attack occurring from several minutes to hours after the end of CGRP infusion, it is possible that exogenous CGRP (likewise many other vasodilator substances) targets a hitherto undefined central site that eventually results in sensory nerve activation and the release of endogenous CGRP.
Efforts to develop a safer and more effective SLIT for inhalant allergens have led to the development of allergoids, recombinant allergens and formulations with adjuvants and substances targeting antigens to dendritic cells that possess a crucial role in initiating immune responses.
It now seems possible to screen directly for therapeutically active substances targeting the CSC subpopulation in eRMS to further advance treatment of this childhood sarcoma.
There are other tumour inhibitory substances targeting ARNT degradation such as curcumin, a major component of turmeric [ 33].
6 The development of new substances, targeted therapies, and immunologic substances has completely changed the former treatment guidelines for metastatic disease in melanoma.
As cell cycle deregulation and tumor growth are intimately linked, the discovery of new substances targeting events in this biochemical pathway would be of great value.
Novel pharmaceutical substances targeting hormonal circuits of appetite control and food intake may also be important agents in the future treatment of AN [ 119].
