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The recommendation criteria do not give priority to substances relevant for worker exposure.
First, the KEGG database (a database of small molecules, biopolymers, and other chemical substances relevant to biological systems) was used to analyse the relationship between MTLD entries and biological processes.
The predictive value of the different in vitro and in vivo assays described here for the identification of HA-protective dietary substances relevant for humans is probably better than that of conventional in vitro test methods with enzyme homogenates.
Inherent properties of the substances relevant to exposure (water solubility, log K ow, Henry constant, persistency) as well as indications of aquatic toxicities (EC/LCx, predicted no-effect concentration (PNEC) values, classification and labelling, e.g. as R50/53) were compiled from multiple sources [24 33].
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Significant elimination of hepatotoxic substances or relevant detoxification resulting in increased hemodynamic stability could be better surrogate parameters to verify the effectiveness of any therapeutical approach.
The report contains the sum and substance of relevant facts uncovered during our investigation.
According to ICH guiding principles, if the response factors of drug substance and relevant impurity are not close, we can use the drug substance as a standard to estimate the levels of impurities with providing a correction factor.
On Friday, Circuit Court Judge Henry Meigs, in Frankfort, Ky., ruled that chemical evidence failed to show the presence of an illegal medication in the colt when he won the race, and that other evidence presented was "wholly lacking in substance & relevant consequence".
His Report on the introduction of a rescued Ornicus orca individual into the Orca Ocean group appears lacking in both substance and relevant fact.
Not only is current substance use relevant for learning self-regulation and various adverse health outcomes, but also both early and high-frequent consumption levels have been connected to future substance misuse [ 11].
(5) Detailed information about drug-consumption for all relevant substances (e.g. onset of drug-use, present substance use, consumption in the last 30 days) obtained by comprehensive semi-structured interviews was recorded.
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