The 33 patients with DUD abused or were dependent on the following substances (number of patients in parentheses): cannabis (28), sedatives (13), stimulants (10), cocaine (9), opioids (2), and other substances (2).
The following variables were included: hospital type (university, teaching, other), hospital size (<= or > 600 beds), ward type (interdisciplinary, surgical, medical ICU), ward size (<= or > 12 beds), number of used AB substances, number of used AB groups, ADs of AB treatment groups and fractions of most used AB groups.
The great heterogeneity of clinical outcomes can be also explained by the different PRP products that have been used: several different procedures have been described to obtain PRP, thus implying qualitative and quantitative differences among substances (number of platelets concentrated, leukocyte content,..) [ 64].
The recorded metadata of data collections includes: details of the data collection, source ID, name, description, source type, number of substance, number of generic chemicals, number of assay results, and link-out which provides a direct connection to the external website of a given data collection.
Finally, applicative protocols can vary widely in terms of amount of substance, number of administrations and timing.
The registration is mandatory and the following data from the register was used in our study: number of patients, the dispensed drug (substance), number of dispensed prescription drugs per patient, the cost of the drug, DDD, number of DDD per patients, the date of dispensing, age, gender, and a unique identifier (personal identification number) of the patient.
Rectangles are stocks or compartments that represent an amount of substance (numbers of trees, size of a tree), and change only via a flow (, e.g., die, grow).
For past poly use of substances, the number of HR individuals reporting use for each substance was higher with the exception of opiates, which was the same.
During 6 visits to the setup, each lasting 180 sec, we quantified for each substance the number of drops that were consumed.
Risk can be assessed based on past medical history of ADEs, substance use, number of medications, and overall burden of disease.
Social condition and substance use (number of people in the household, tobacco use, alcohol use, soft drugs and hard drugs) were extracted by trained nurses.
