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Among the enhancements to the comparative studies, the manuscript presents the process settled within our company for a better integration of the transfer study into the method life-cycle, just as proposals of generic acceptance criteria and designs for assay and related substances methods.
The role of WADA in this respect is to coordinate information exchange and alert the IFs and all involved stakeholders of new information on possible doping substances, methods or approaches that could potentially help uncover doping.
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The percentage relative standard deviation of the results for related substances method was evaluated and found to be 0.4-1.5 0.4-1.5
Related substances method precision was demonstrated by analyzing six separate Lafutidine sample solutions that were prepared by spiking the related substances viz., Imp-A, Imp-B, Imp-C and Imp-D at specification level.
Malondialdehyde (MDA), a marker of lipid peroxidation, was measured using thiobarbituric acid reactive substances method [ 16].
T1 of oils from control and transgenic plant seeds was evaluated via the TBARS (thiobarbituric acid reactive substances) method.
To determine a lipid peroxidation in fish samples, the TBARS (thiobarbituric acid reactive substances) method described by Lushchak et al. (2005) was used.
"Pure placebos" refer to inert substances or methods, whereas "impure placebos" include substances or methods which do have a known pharmacological or physical activity but which cannot be expected to have any direct therapeutic effects for the respective disease and in the chosen dosage.
The agency maintains a detailed list of prohibited substances and methods, and it has devised the list to address not only specific drugs, but categories of potential drugs and methods to ensure that rules cover new methods not yet known to them.
First, athletes' urine and blood samples are analysed according to the current list of prohibited doping substances and methods.
The prohibited list is reviewed annually and is subject to change as new doping substances or methods are identified.
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