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Whilst some suggest the use of phthalate-free substitutes in hospitals [ 15], others state that inadequate health risk assessment of potential alternative substances limits the possibility of replacing DEHP in medical devices [ 16].
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A difference in hemoglobin adduct levels could be detected between garage workers and controls using the sum total of all five nitrated-PAHs; but the general conclusion was that high background exposures to these substances limited the usefulness of this quantitative approach.
Vinegar has been found to contain chemicals which can dissolve this substance, limiting the ability of nits to maintain their grip on human hair.
Because pathogens involved in implant associated infections are diverse and bacteria in biofilms are protected from antibiotics (Ceri et al. 1999), the restricted activity of these substances limits their clinical effectiveness, especially in infections involving antibiotic-resistant bacterial strains (e.g. MRSA) (Liu et al. 2012).
In Europe the Restriction of Hazardous Substances (RoHS) directive limits the use of many toxic materials in new electronic products sold in the European Union.
This test, however, requires [14C] labeled test substances, which clearly limits the scope of the test.
Because photosynthetic pigments are one of the first targets of UV-B radiation in plants, the experimental design is based on the ability of the tested substances to limit the degradation of sodium magnesium chlorophyllin (SMC), a derivative compound of natural chlorophyll.
Currently, scientifically appropriate simulation methods for the analysis of surfactants in anaerobic conditions within a WWTP (OECD 314 [2]) require radiolabeled test substances, which limit the scope of such a method.
Some of them are already being tested in clinical trials., Aminoguanidine was one of the first substances identified limiting the formation of AGEs.
This raises concern as to the ability of polyphenols derived from green tea to afford protection from mutagenic substances or limit the progression of established cancer.
Our approach assumes that the toxicological importance of a response profile generated in qHTS applications should be determined by a robust framework to impartially classify tested substances and limit the return of false negatives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com