Due to this lack of appropriate testing tools, recent research is increasingly interested in this substance group [1].
With the PCDD/Fs a substance group is involved, which has not been regulated so far, but may provide the widest consequences.
As highly persistent final degradation products of many other PFASs, PFAAs are a relevant group regarding environmental and human exposure, even though being a small substance group within the whole PFASs group, consisting of at least 3000 substances [9].
One example of this substance group is the phagocytes S100 proteins [ 24].
Biologics are a novel substance group with wide use in rheumatic and inflammatory diseases.
The most frequently prescribed substance group was non-steroidal anti-inflammatory drugs (NSAIDs; see figure 1), representing 36% of all substances.
Compared to Germany, where up to 28% of prescribed substances are narrow-spectrum penicillins [ 8], in Austria, this substance group accounts for only 7% of prescriptions.
To report indications, substance group, origin, self-rated improvement of conditions treated, tolerance, duration of use and perceived adverse drug reactions (ADRs).
Daughton and Ternes (1999) coined the term "lingering environmental toxicants," identifying personal care products, pharmaceuticals, and endocrine disruptors as integral parts of this substance group.
One safe [ 1] and promising substance group for this aim are the statins, where were primarily developed to inhibit cholesterol biosynthesis [ 2] and reduce its plasma levels [ 3].
