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These substances are expected to act as pro-transition state analogues.
These substances are expected to contain certain poly aromatic hydrocarbons (PAH) known for their CMR and PBT properties.
In addition, anthracene and derivatives, which are already included in the candidate list as SVHC were not considered in the dossiers though these substances are expected to be constituents of the screened UVCBs.
The trade-off between the rate of functioning of the metabolic machinery and oxidative stress lies at the very core of some of the evolutionary theories of aging [1], [3], [17], [18], as individuals with a high production of oxidative substances are expected to be trading current investment in fitness traits against residual reproductive value.
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In urban environments, mainly in areas where population and traffic density are relatively high, human exposure to hazardous substances is expected to be relevant.
However, some of the notified substances were not further supported by submitting a complete dossiers (e.g., chlorpyrifos, phoxim), so that the actually available number of biocidal active substances is expected to decrease.
Moreover, sensitivity to harmful substances is expected to be modified not only when metabolic processes are altered but also when the target organ of the toxic effect is affected by disease [ 3].
The in vitro data needed to set an exposure standard for a substance are expected to consist of responses from a suite of in vitro tests for the identified TPs, measured in cells from many different individuals at a number of different exposure concentrations.
Substances that are expected to exert a specific mechanism (MoA4) were not determined in the group of industrial chemical confirming the initial subdivision of the dataset into chemicals and pesticides.
However, we shall consider below generic materials instead of specific substances, since many features are expected to be almost insensitive to the chemical composition (Wright, 1987).
6 Mental health and substance abuse treatment costs are expected to increase to US$239 billion by 2014 but continue to fall as a share of all health spending.
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