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The tetrazolium test for skin carcinogenicity was performed with different doses of (i) a strong, complete carcinogen with moderate cytotoxicity, 20-methylcholanthrene; (ii) a weak carcinogen with strong cytotoxicity, the promoter 12-O-tetradecanoylphorbol-13-acetate 12-O-tetradecanoylphorbol-13-acetate 12-O-tetradecanoylphorbol-13-acetate 12-O-tetradecanoylphorbol-13-acetate 12-O-tetradecanoylphorbol-13-acetate
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Following a conservative approach, substances with very low or no immediate concern are filtered-out.
The fluorine-carbon bonds are extremely stabile conferring these substances with very high thermal and chemical stability.
Endocrine activities of the remaining substances cannot be excluded; however, because the structural alerts perform much better for substances with (very) high estrogenic and androgenic activities, there is reasonable probability that the most hazardous candidates have been identified.
The aims of the present study were (1) to develop a passive dosing approach for aquatic toxicity testing of liquid substances with very high Kow values and (2) to apply this approach to the model substance dodecylbenzene (DDB, Log Kow = 8.65).
Bisphosphonates (BPs) are well-known substances with very efficient antiresorptive properties [ 1, 2].
Bisphosphonates (BPs) are well-known substances with very efficient antiresorptive properties.
Although a substance's solubility in water should have been a primary consideration in determining whether to test for aquatic toxicity, fish testing was nevertheless conducted on substances with very low solubility.
Moreover, NO is a volatile substance, with a very short half-life, and therefore its moment-by-moment quantification in a specific vascular area is almost impossible.
In addition to this, as alum is a non-physiological substance with a very recently elucidated mechanism [ 3– 9], it is still unknown as to how this adjuvant may interact with preventative therapeutic agents.
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