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An efficient generic static headspace gas chromatography (HSGC) method was developed, optimized and validated for the routine determination of several residual solvents (RS) in drug substance, using a strategy with two sets of calibration.
The USP monograph describes an HPLC method for seven impurities in the amiodarone drug substance using a L1 column, 4.6 mm × 150 mm, 5 μm packing (PF listed ODS2 GL-Science, Inertsil column) at 30 °C with detection at 240 nm.
One method commonly used for evaluation of in vitro antiviral effect involves titration of residual virus infectivity after extracellular action of the test substance using a plaque reduction assay.
The very small amount of drug transferred into tissue during the retrodialysis (90 ng of each substance using a flow rate of 1.5 μl min−1 over 30 min) resulted in blank electropherograms after a wash-out period of 30 min.
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For lower resolution the corresponding time is three hours for 700,000 substances, using a conventional scanner system.
A final solution to keep wine from mixing with the oxygen in the bottle is to physically separate the 2 substances using a thin plastic barrier.
And a graphic with the article misidentified a substance used as a layer between some joints in the glass observation boxes at the Sears Tower.
Phlox then reports that Khouri's body contained traces of a substance used in a zero-gravity mining facility.
Knight JR, Sherritt L, Van Hook S, Gates EC, Levy S, Chang G. Motivational interviewing for adolescent substance use: a pilot study.
High LDQ scores are associated with cognitive preoccupation with substance use, a compulsion to use, continual use, planning and organizing future use, maximization of the subjective experience of substance use, a reduced repertoire of behaviour with the primacy of substance use and substance use as an existential coping strategy.
Substance use is prevalent among American youth, and its associated negative consequences render adolescent substance use a significant public health problem.
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