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Geldanamycin, a natural substance that modulates Hsp90 function, was previously shown to induce a heat-shock response through the activation of heat shock factor 1 (HSF1); it also reduces polyQ aggregation in mammalian cells (Ref. 104) and suppresses α-synuclein neurotoxicity in flies (Ref. 105).
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Many substances that modulate neuronal activity in the amygdala alter anxiety.
Several substances that modulate apoptotic processes have been used in order to protect the hepatic parenchyma.
Hong et al. used genome-wide profiling to identify genetic biomarkers for metastasis prone colorectal cancer as well as their perturbagens, substances that modulated their expression.
The endothelium is composed of cells that not only serve as a physical barrier between blood and tissues but also act to maintain vascular homeostasis, the dynamic balance between vasodilatation and vasoconstriction, by synthesizing and releasing substances that modulate vascular tone and structure.
In enteric bacteria, extracellular amyloids known as curli are the major extracellular polymeric substances that modulate biofilm organization and colonization by adhering to surfaces and anchoring cells to the biofilm2,3.
The importance of these results lies in the principal ability to manipulate the social rank of mice by developmental exposures to substances that modulate BW.
Although controversial, both stages are considered to independently mediate tissue damage via the production of directly injurious reactive oxygen species (ROS) [ 24], as well as substances that modulate a local and systemic inflammatory response.
Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
A compound substance is a substance that has other substances as proper parts.
The specialized equipment that modulates the current can't be fit into every washer and electric blanket, after all.
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