Sentence examples for substance peak from inspiring English sources

Peaks were well separated from thedrug substance peak (5.79 min).

Isocratic elution wasobserved to be more efficient in achieving optimum separation of impurities from eachother with respect to drug substance peak.

The present method was developed by testing different stationary phases to achievegood separation of the impurity peaks from drug substance peak.

The molecular mass of the purified anti-Vibrio substance (peak 1 in Fig. 2) was 423.2076 Da, as determined by Orbitrap Fusion MS. The MS analysis also revealed a plausible chemical formula (C20H30N3O7) for the substance (Fig. 6).

The mixture was separated with the following gradient: 0 to 2.0 min isocratic at 50% B, 2.0 to 32.0 min linear to 70% B, 32.0 to 38.0 min isocratic at 70% B, 38.0 to 38.5 min linear to 50% B, and 38.5 to 50.0 min isocratic at 50% B. For the measurements of IC50 values, isocratic elution was applied, taking care that the substance peak showed separation from the injection peak.

Unidentified substance peaks acquired during standard screening were subjected to an in-depth analysis: the sample solution was again diluted with methanol to a concentration of approximately 10 μg/mL and injected directly into the Q-TOF-MS (maXis, Bruker Daltonik GmbH, Germany) instrument with a syringe pump at a flow rate of 5 μL/min.

Two structurally related substances (peaks 2 and 3 in Fig. 2) were also characterized.

The first thermal event for the BZ is an endothermic one, without mass loss, and represents the melting of this active substance (HF peak  = 90.1°C; T onset  = 76.23°C; ΔH fus  = 107.94 J·g-1).

The names of the substances and peak areas detected in this study are listed in Table  3.

The active substances in peak I were identified as an isomeric mixture of 9,12-oxy-10,13-dihydroxyoctadecanoic acid and 10,13-oxy-9,12-dihydroxyoctadecanoic acid, collectively designated tetrahydrofurandiols (THF-diols).

Tandem MS data confirmed that the compounds were MC variants, as for all three substances significant peaks at m/z 375.19 (z3[7|1][5–7] − C9H10O ion) as well as fragments at m/z 135 and the corresponding [M − C9H10O]+ fragments could be observed, ions characteristic for MCs containing the Adda substructure [8, 9, 10].