This strong correlation, including the timing of the onset and end of abdominal contraction periods, suggests that at least in mosquitoes circulation is the primary function of these contractions and that tracheal ventilation could be a subsidiary outcome.
A cost-effectiveness analysis on our subsidiary outcome measure would therefore not be appropriate.
We also considered the subsidiary outcome of cervical intraepithelial neoplasia grade III or more severe disease.
There is good reason to rank tremor, where present, as a subsidiary outcome to rigidity: tremor decreased with increase in flexor tone, and vice versa.
Everything else is a subsidiary issue.
Subsidiary clinical outcome measures include time to first bleed and a descriptive analysis of all severe bleeds.
Clinical validity was assessed by examining the association of each measure with occurrence of coronary events (CHD death and non-fatal infarction, as was prespecified as the primary outcome for subsidiary analyses in the protocol) in all patients over 5 years of follow-up.
This will be explored in subsidiary analyses to the main outcome of overall sustained abstinence.
In addition to the main analysis, that will report treatment group effects for the primary outcome measure, a subsidiary analysis will use a multiple linear regression model to investigate the relationship between each patient's EQ-5D score at 12 months and the treatment arm, age, gender and dementia for each patient.
In addition to the main analysis, that will report treatment group effects for the primary outcome measure, a subsidiary analysis will use a multiple linear regression model to investigate the relationship between each patient's EQ-5D Score at 12 months and the treatment arm, age, gender, dementia and fracture displacement for each patient.
