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Currently, the WHO (World Health Organization) classifies gliosarcoma as a subset of grade IV gliomas (Louis et al., 2001).
These observations support the idea of the PVI+/membranous NHERF1- expression phenotype as a useful marker for the identification of a subset of grade 2 tumors with clinical high risk of poorer prognosis.
CXCR4 was expressed uniformly across a spectrum of normal, and a panel of invasive breast tumour cells but only a subset of Grade III tumours expressing high CXCR4 correlated with poor prognosis.
Therefore, we also performed a correlation between serum Her-2/ neu ECD levels and pHer-2/ neu expression in the subset of grade 3+ Her-2/ neu overexpressing tumours.
Grade 1 and a subset of grade 2 HD samples possessed Z.K values that were comparable to those of unaffected individuals; however, a majority of grade 2 samples and grade 3 samples possessed Z.K values that were substantially lower than all other samples.
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Outcome comparisons were not performed for subsets of grade 3 malignant glioma patients because of the small sample size.
A representative subset of four grade 3 and four grade 1 and 2 primary breast cancer cell lines was used for further phenotypic and functional studies.
The GGI was able to further stratify the subset of histological grade 2 patients into two subgroups: a grade 1 gene-like profile and a grade 3 gene-like profile with clearly different rates of relapse.
Increased p53 protein was detected in a subset of low-grade vs high-grade astrocytomas (Chozick et al, 1994a).
Interestingly, although activating point mutations in KRAS in ovarian cancer are observed predominantly in low grade serous subtype and rarely in high grade cases, of the 25 samples with an amplification at KRAS of at least 0.8 (log2) in amplitude, all but one were high-grade serous, suggesting an alternative mechanism for activation of this pathway in a subset of high grade serous carcinomas.
Tandem duplication involving the KIAA1549 and the BRAF kinase genes results in a gene fusion that has been recently characterized in a subset of low grade glioma While there is no clear evidence that the KIAA1549-BRAF gene fusion has an effect on prognosis, it is an attractive target for therapy development and as a diagnostic tool.
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