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Of these five mutants, one (iv52 ) lacked observable gland reporter expression, one (iv36 ) lacked expression in a subset of glands and showed apparent defects in g1P migration, and three (iv37, iv38, and iv50 ) had wild-type numbers of expressing cells with abnormal morphology of the gland extensions.
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The extensive diversification in expression of this family of proteins provides two lines of evidence for a pheromonal role for ABP: 1) different patterns of Abpa/Abpbg expression in different glands; and 2) sexual dimorphism in the expression of the paralogues in a subset of those glands.
In a lactating mouse a subset of mammary glands are surgically sealed (to induce stasis and involution).
However, it was noted that a subset of mammary glands from δKO mice at involution days 4, 6 and 8 tended to have slightly more epithelial cells and to be more pleiomorphic with regard to adipocyte size and shape compared with glands from δWT mice, suggesting that PKC δ may have a role in the composition or organization of the mammary gland stroma.
Indeed, our results suggest that c-Myc plays a role in a subset of mammary gland progenitor cells, the Pi-MECs.
A subset of Harderian gland cells, the type B cells (Fig. S9), form multilamellar bodies by fusion of lipid droplets and primary lysosomes (Fig. 4 ).
The RB4Ea12 scFv epitope was originally described as GlcNS6S-GlcUA-GlcNS3S6S-IdoUA-GlcNS[+/−3S]6S (where GlcUA is glucuronic acid) with an absolute minimal requirement for 6-O sulfation, which would suggest that the protein bands that were observed by immunoblotting probably represent only a subset of salivary gland HSPGs [ 21, 37– 37].
Conversely, we observed derepression of luminal-specific miR-34a, miR-205 and miR-222 in the MaSC/basal subset of Ezh2-deficient glands (data not shown).
The first FGFR fusion observed in epithelial cancers, FGFR1-PLAG1, was found in a subset of pleomorphic salivary gland adenomas, and involves FGFR1 as the 5′ partner upstream of PLAG1, the known driver of salivary gland tumors [ 91].
Loss of function for many TSGs has been linked to unique morphological phenotypes for subsets of mammary gland tumors.
The ability to evaluate the in vivo repopulating activity of distinct subsets of mammary gland cells has enabled the prospective isolation and characterization of putative stem cells and/or progenitors from both mouse [ 31, 32] and human [ 7, 28, 29] mammary tissues, and has led to the identification of stem cell-associated antigenic markers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com