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In contrast, the IL-4/STAT6 pathway regulates only a subset of disease markers that did not affect renal pathology.
In general, outlier analysis offers a unique and powerful approach for the identification of key pathogenetic genes involved in a subset of disease samples.
The cause for this subset of disease has been linked to gene mutations in amyloid precursor protein (APP), presenilin 1 (presenilinesenilin 2 (PSEN2) (reviewed in [1]) and duplications of APP [2].
Another study noted that ~44% of a curated subset of disease genes were found to have orthologs in the yeast Saccharomyces cerevisiae [ 8, 9].
Some of these are also associated with certain clinical symptoms or subset of disease and are useful in monitoring certain organ involvement and predicting outcome.
This procedure is illustrated by Figure 2. Then we repeated the same procedure for all SNPs in the combined sequence subset of disease samples.
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In the second part we review the current literature available on a selected subset of diseases, namely, dementia, schizophrenia, multiple sclerosis and others, and try to extract for each disease the common findings and main differences between reports.
A subset of disease-prone individuals is at risk for recurrent acute pyelonephritis (APN), severe renal dysfunction and even end-stage renal disease and genetic markers of susceptibility have recently been described in this patient group [15], [16], [17].
While its use clinically at the current time is limited to a subset of diseases, its potential in treating multiple human diseases is immense.
Although a subset of diseases can be linked to the presence of a single causative pathogen, there is a growing recognition of the need to study complete or near complete microbial communities [66], [67].
Similar patterns were observed for the subset of disease-associated alleles that have been verified in multiple studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com