Thus, we think it likely that Rab23's function in ciliary membrane targeting is specific to a subset of cilia-localized cargoes.
These results demonstrated that Rsph9 protein was expressed and localized in a subset of CPEC cilia in juvenile swine and adult mouse, consolidating the proteome data.
A subset of neuronal cilia harbor certain G-protein coupled receptors (GPCRs) including somatostatin receptor 3 (SSTR3) (Händel et al., 1999), serotonin receptor 6 (5HT6) (Brailov et al., 2000; Hamon et al., 1999), melanin-concentrating hormone receptor 1 (MCHR1) (Berbari et al., 2008a; Berbari et al., 2008b), and dopamine receptor 1 (Domire et al., 2011).
Interestingly, the remaining genes displayed subsets of motile cilia phenotypes upon knockdown, allowing us to parse the molecular signatures of different types of motile cilia.
Subsets of specific cilia also have long or short rootlets that may be striated, and that extend proximally from the TZ often beyond the PCMC into the dendrite (Ward et al., 1975; Perkins et al., 1986).
Several rhodopsin family G-protein coupled receptors (GPCRs) are specifically localized to a subset of neuronal primary cilia.
C. elegans lacks motile cilia; however, a subset of its neurons grow nonmotile sensory cilia that are exposed to the external environment.
The findings of Ishikawa et al. suggest that TTC26 may help to transport a specific subset of proteins into the cilia.
It will be interesting to determine whether similar to cilia morphology in a subset of neurons, PCMC morphology and vesicle content are also dynamic and modulated by experience and context in C. elegans.
