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The Haemoglobin-beta domain is present only in chordates and the interactions between this domain and the Globin-subset domain is predicted only in human and mouse species.
Domain support offers two subsets: domain interactions that have been derived from crystal structure analyses and domain interactions that have been computationally predicted by different methods (see Supplementary Data File 3 ).
The first is the complex survey design that mandated incorporation of design factors and survey weights, for overall analyses and analyses within the subsets (domains).
To test the robustness of our results, we tested the GO enrichment in the subset of domain families with ≥ 75% genes of a family only having one domain.
Gene Ontology biological processes significantly enriched in C. reinhardtii retained duplicates in a subset of domain families.
However, recent work proposed that a subset of domain architectures could have appeared several times independently.
In the process of enumerating all possible subsets of domain architectures, many putative subsets may be produced.
Functions reported at the protein level may correspond to the whole protein, a subset of domains, or even a single domain.
For clarity, Pfam-B domains are derived from a subset of domains present in the ProDom database.
This suggests that there are additional mechanisms maintaining early replication of these domains, whereas we have identified a subset of domains at which esBAF presence has a major effect on replication timing.
We enumerated all possible subsets from domain architectures in the training set and estimated each subset according to 4 measurements: comprising existence, succinctness, consistency, and simplicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com