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Although surgery achieves excellent local control, within 5 years, almost 50% of patients have a relapse and, subsequently, progression to systemic disease developing.
Subsequently, progression of the individual cancer may be monitored by transcriptomics to detect progression, recurrence and metastasis.
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In patients with CA-125 first progression who subsequently progressed radiologically, a delay of 2.3 months was observed between the two progression types.
The majority of patients have a rapid early response but subsequently progress with a median progression-free interval of 6 7 months (Chapman et al, 2011; Hauschild et al, 2012).
We hypothesized that restoring intracellular redox control would inhibit inflammation and subsequently tumor progression.
The integral role of EMT in disease was taken one step further with evidence supporting a key role in tumor initiation and, subsequently, the progression of metastatic disease [3].
Theoretically, prescribing brace treatment 16 hours instead of 23 hours per day (patients are allowed to attend school free of their brace) could lead to a higher rate of compliance, and subsequently reduce progression rate of patients with AIS.
Twenty-two patients who demonstrated a clinical response (PR) to CF therapy were biopsied prior to the initiation of therapy and subsequently following progression of disease after chemotherapy.
Since these membrane disruptions are important for neuronal toxicity, their blockade would be expected to inhibit synaptotoxicity, neurodegeneration and subsequently AD progression.
(The most desirable design, prospectively ascertaining incident infections and subsequently monitoring progression, would likely be prohibitively difficult).
Tumor measurements were performed every other cycle during the treatment course and every 3 months subsequently until progression.
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