When considering methods for sequencing the smallpox virus genome in 1991 (12), a whole-genome shotgun sequencing method was discussed and subsequently rejected owing to the lack of appropriate software tools for genome assembly.
Two patients who commenced therapy were subsequently withdrawn owing to incorrect histological diagnosis (one mixed mullerian tumour, one metastatic carcinoid).
In the 1981 survey, 3940 adults participated (64% of those eligible), with 14 subsequently excluded owing to a diagnosis of malignancy before the survey date.
Smoking status was the only variable that was initially considered for entry into the models but not subsequently used, owing to collinearity with pack years.
Clinical trials of an anti-CD19 CAR T-cell therapy for the treatment of acute lymphoblastic leukaemia has suggested that this might occur (Grupp et al., 2013) and, recently, data has been reported on a group of patients that initially showed a complete response but who subsequently relapsed owing to the presence of blast cells (Box 1) that no longer expressed CD19 (Maude et al., 2014).
After July 2007, owing to a protocol amendment in the second half of the study, capecitabine could subsequently be continued until disease progression.
He was subsequently transferred to our center owing to the difficult control of his blood glucose level by using different insulin regimens.
In addition, cartilage affected by degeneration show reduced capacity to absorb compressive load and subsequently provoke crepitus and pain owing to the destructed cartilage surface [ 2].
Ninety-one participants were subsequently excluded from the study owing to various reasons (see Fig. 1, the flow diagram), yielding 153 participants who were included in the final data analysis.
During the carboplatin initiation phase, seven patients (7%) withdrew owing to excessive toxicity and, subsequently, four patients (9.3%) receiving docetaxel and three (7.9%) receiving docetaxel irinotecan discontinued therapy owing to toxicity, giving a total withdrawal rate of 14%.
