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These molecules bind to cell surface receptors and are subsequently internalized by endocytosis, resulting in cell death.
The results as shown in Figure 8c demonstrate that HMSNs adhered to the plasma membrane were subsequently internalized by a vesicle-mediated endocytosis process.
"All these are attributes they bestowed upon their ogre and subsequently internalized in an attempt to merge with their ideal," Sultan writes.
This complex is subsequently internalized by receptor-mediated endocytosis (Lill et al., 2012) and acidified in the endosome, facilitating the release of Fe3+ from holo-Tf (Zhao et al., 2010).
There is evidence that the receptor in the closely related duck hepatitis B virus is carboxypeptidase D. The virions bind to the host cell via the preS domain of the viral surface antigen and are subsequently internalized by endocytosis.
Activated receptor-ligand complexes are rapidly deactivated (i.e., desensitization) and the desensitized receptors are subsequently internalized and eventually re-expressed back to the cell surface.
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Our data suggests that upon ligand activation, CysLT1R is tyrosine-phosphorylated and released from heterodimers with CysLT2R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner, thus, enabling Erk1/2 signaling and downstream transcription of the COX-2 gene.
Mannose-recognizing lectins are exclusively expressed on macrophages; they recognize glycoproteins with mannose, N-acetylglucosamine, and fucose residues and subsequently internalize them [ 13, 14].
The scavenger receptors (SRs) are a structurally diverse group of pattern recognition receptors (PRRs) which were originally defined based on their ability to bind and subsequently internalize acetylated low-density lipoprotein (acLDL).
This finding supports a model in which the small cRGDfK-Ag2S QDs extravasate into tumor tissue, bind to ABIRs, and subsequently internalize in tumor cells via receptor-mediated endocytosis.
This was hypothesized to serve the purpose of storing up free ferric ions which could subsequently be internalized into the cells by the siderophores, in order to safeguard against a sudden dip in iron concentration.
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