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The benefit of a computer-generated model is that it allows for the integration of different types of data that can subsequently be updated, manipulated and changed quickly (Cancelliere et al. 2014).
Our approach towards structural improvement is also an example of the iterative "cycle of knowledge" approach [ 24], where the model is first used to guide biological research and can subsequently be updated and improved as specific new knowledge becomes available.
Here we propose an alternative, 'top-down' mechanism, whereby an approximative model of the whole system is built initially; this model can then be used to guide experimental design and can subsequently be updated as specific knowledge becomes available from experimental results, following the iterative 'cycle of knowledge' approach [ 23].
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A BBC spokesperson said that its coverage was prompted by "safeguarding warnings" and had "subsequently been updated to reflect that fact-checkers now say aspects of the 'Momo' story is a hoax".
We note that the NCI identifiers themselves may not necessarily persist across different versions of the NCI database, which was version 3 at the time of the original curation and has subsequently been updated to version 4 in 2012 [20].
Our results indicate a shorter time to publication associated with the review subsequently being updated.
Multivariate analyses revealed that shorter time to publication was associated with the review subsequently being updated (hazard ratio, HR: 1.80 [95% confidence interval, CI: 1.39 to 2.33 years]) and longer time to publication was associated with the review having two published protocols, indicating changes to the review plan (HR: 0.33 [95% CI: 0.12 to 0.90 years]).
This has subsequently been updated to be more flexible, reflecting that research on the context, the intervention and the evaluation may be conducted simultaneously rather than sequentially [ 14, 17].
Database URL: http://yeast.sf.net/ In 2007, a community effort to integrate previously published genome-scale reconstructions of the yeast metabolic network (1, 2) produced a 'consensus' representation of yeast metabolism (3), which has subsequently been updated through iterative collaborative curation by multiple research groups (4, 5).
Be updated.
In the North Netherlands, the first guidelines for the treatment of patients with DCIS were developed in 1992 and subsequently they have been updated every 2 or 3 years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com