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To mimic this sero-positive status and to determine whether preexisting heterosubtypic immunity affects responses to subsequent vaccination with H5N1ca vaccine viruses, ferrets were primed intranasally with live attenuated trivalent seasonal influenza vaccines (LAIV) or medium control prior to vaccination with the H5N1 HK03 or VN04 ca viruses.
These data demonstrate that PCV13 primed the immune system for a booster response to subsequent vaccination with either vaccine.
Through the combination of traditional serological analysis, high throughput sequencing applied to the analysis of the diversity of the repertoire of B cells and bioinformatics analysis, we have studied the clonal response to the 2008/2009 trivalent influenza vaccine, as well as to a subsequent vaccination with the 2009 pdmH1N1 influenza vaccine and the 2014/2015 trivalent influenza vaccine.
The purpose of this study was to determine if previous vaccination with a VSV-based LASV vaccine would reduce the efficacy of subsequent vaccination with the VSV-based EBOV vaccine.
We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine.
Moreover, polysaccharide vaccines may induce hyporesponsiveness to subsequent vaccination, in particular for serogroup C [ 17].
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It has already been established, for example, that the parental attitudes and behaviours which predict receipt of primary vaccines at an early age predict subsequent vaccinations equally well [ 19].
bPrimary immunization was defined as two subsequent vaccinations within 2 to 6 weeks with the same vaccine strain.
dPrimary immunization was defined as two subsequent vaccinations within 2 to 6 weeks with the same vaccine strain.
It had been neutered and had been vaccinated at 10 months of age with an adjuvanted inactivated vaccine against rabies (Rabisin; Merial, Lyon, France), but no subsequent vaccinations were given.
The majority of cases developed within a few days following vaccination and more often after the initial vaccination than subsequent vaccinations, although several patients developed recurrent inflammation with each vaccination.
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