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In this case, hyperactivated PARP-1 would lead to rapid ATP depletion and to irreversible cellular energy failure and necrotic-type cell death subsequent to disruption of oxidative metabolism.
The comparatively high FGM levels in non-consigned mares subsequent to disruption of their group stability indicate that the paradigm of increased abortion-risk in pregnant mares as a result of social stress should also include consideration of the susceptibility of mares in a group from which others have been removed.
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The time courses of these changes are delayed compared with the axonal responses described above, indicating that altered gene transcription occurs subsequent to axonal disruption.
It is noteworthy that the amounts of Smac that could be detected in cytosolic extracts subsequent to cell disruption were significantly higher in C-XIAP-C-expressing cells.
We then developed a workflow for single muscle fiber proteome analysis on the basis of a recent method, in which all preparation steps subsequent to mechanical disruption are performed in a single vessel, thereby minimizing sample loss (Fig 1A and Supplementary Methods section) [ 19].
Furthermore, expression changes of a Pitx2-inclusive cardiogenic sub-transcriptome were revealed downstream of calr deletion, providing novel bioinformatic support for cardiogenic disruption subsequent to calr derangement.
Subsequent to cap thinning a disruption or tear in the cap causes blood to enter the lipid core of the plaque determining an initial phase of intraplaque haemorrhage.
An early effect of CCl4, BrCCl3, and 1,1-dichloroethylene is destruction of the Ca2+-sequestering ability of the endoplasmic reticulum, and it has been suggested that this lesion leads to subsequent disruption of other cell functions.
Memory consolidation has traditionally been described as a process in which a newly acquired, labile memory trace is converted into a stable form that is resistant to disruption by subsequent interference from other experiences1.
Cells that fail to repair damaged DNA before entering mitosis may exhibit chromosomal strand breaks, leading to disruption in subsequent cell cycles resulting in a defective colony formation [41].
If these scenarios indicated that an inversion likely was shared between two or more genera, the taxa were coded as having an endpoint even if the endpoint has been lost due to disruption by subsequent events.
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