At pH 5.5, the transition is complete, and the protein further unfolds, resulting in the exposure of its C-terminal hydrophobic TH8 9, leading to subsequent aggregation in the absence of membranes.
The occurrence of misfolded p53 proteins can lead to aggregation and subsequent ubiquitination in the cell, leading to p53 inactivation [648], [649].
Our results show that the chondroinductive polyacrylates were not only able to induce chondrogenesis, but were also able to support subsequent aggregation.
This transition leads to subsequent gelation and/or aggregation that stabilizes the β-phase at higher temperatures and leads to a large hysteresis in the transition temperature.
For automated syndromic surveillance, CCs must be classified into predefined syndromic categories to facilitate subsequent data aggregation and analysis.
Therefore, we propose a model in which Aβ43 aggregates either with itself or with other highly aggregation-prone Aβ variants to seed subsequent Aβ42 aggregation.
Recent studies on amyloid disease-related proteins such as β-amyloid and prion have pointed out that conformational alternation and subsequent aggregation to form amyloid fibrils play a key role in such fatal diseases.
Proteins are shown to be affected by the filtration which would result in structural alterations of the proteins that lead to their subsequent aggregation and inactivation [28] [33].
Platelets then become activated to trigger subsequent aggregation of other locally activated platelets via fibrinogen-mediated interactions with activated platelet integrin GPIIb-IIIa.
Owing to the amphiphilic nature, the [Boc-Cys (PVim -Trp-OMe] bioconjugate undergoes sPVim -Trp-OMe]f-assembly into PVim -Trp-OMe]es and their subioconjugateondary aggregation into spherical micellar aggregates (nanospheres) in water.
Light scattering experiments show that increasing temperature induces hydrophobic associations and subsequent aggregation leading to gel formation which is irreversible.
