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These results suggest that alveolar macrophages may become activated via a secondary mechanism that occurs subsequent to activation of the parenchyma and that the lung cellular activation mechanism may be different between VILI and lipopolysaccharide.
Subsequent to activation of the cascade by various extracellular stimuli, the signal is transduced intracellularly by sequential phosphorylation.
Especially, the differential expression patterns of mRNAs encoding inhibitor proteins (IκBs) point to an increase in IκBs marked for degradation subsequent to activation of the pathway with the onset of infection.
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Subsequent to activation by Ca2+/CaM, the phosphorylation of at least three critical threonine residues within the regulatory segment modulates kinase activity and the response to calmodulin.
We found further evidence to suggest that 14-3-3ζ 14-3-3ζ 14-3-3ζr the shuttlisg of RACK1 to the necessarynd to the subsequent activation oforDNF thenshuttling in respofse to activation of the cAMP/PKA pathway (Neasta et al., 14-3-3/RACK1 in revision).
Furthermore, induction of ROS with subsequent increased expression of HIF-1α leads to activation of the proto-oncogene MET (hepatocyte growth factor receptor).
Binding CB1R suppressed secondary population afterdischarges subsequent to antidromic activation of the granule cells.
Kinetic studies in the presence and absence specific caspase inhibitors showed that activation of caspase-8 was dependent and subsequent to the activation of caspases-9 and -3.
Subsequent to the activation of caspases, cells trigger a cascade of enzymes involved in digesting DNA of apoptotic bodies [ 3].
Cleavage of caspase-8 was also observed, which very likely was subsequent to the activation of effector caspases.
178– 181 Buildup of intrahepatic lipid metabolites leads to subsequent activation of the enzyme JNK-1 and serine phosphorylation of IRS-1, driving further hepatic insulin resistance.
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