The intracellular activation of a phagocyte is initialized by the phosphorylation of p47 PHOX and the subsequent translocation of the entire cytosolic complex to the membrane, where it associates with cytochrome b558 and forms the active oxidase [ 43, 46, 47].
The B subunits of SLT-1 are essential for binding a specific glycolipid receptor and the subsequent translocation of the toxin into the endoplasmatic reticulum (ER) of the host cell.
The release of these proteases from azurophilic granules was not blocked by NEi, indicating that oxidation promotes protease release by triggering NE dissociation from the complex without affecting the subsequent translocation across the membrane and without requiring NE activity during this step.
Western blotting, EMSA and immunofluorescence results revealed that EEPC inhibited the LPS-induced degradation of IκB-α and the subsequent translocation of the p65 subunit of NF-κB from the cytosol to the nucleus, and markedly attenuated LPS-induced NF-κB binding activity.
We hypothesized that the induction of enzymes involved in the biosynthesis of RFOs may be an attempt to reduce the level of sucrose in the phloem of infected leaves, although this strategy does not appear to be effective in preventing the accumulation of starch in leaves and the subsequent consequences on the translocation of nutrients from source to sink organs.
Ligand binding induces gamma-secretase-mediated Notch cleavage and the subsequent translocation of the Notch intracellular domain (NICD) in the nucleus, where it interacts with RBP-J proteins to function as a transcription factor for downstream target genes, including that of the Hes/Hey family.
In the NF-κB pathway, TPL2 functions downstream of IKK-β, and it does not regulate the degradation of IκB-α or the subsequent nuclear translocation of the p50 or p65 subunits but is instead involved in the phosphorylation of p65 (Waterfield et al., 2003).
Treatment of VSMCs with TRAIL or TNF- α induced the degradation of I κB α and the subsequent nuclear translocation of the NF- κB p65 subunit within 60 min following treatment.
We demonstrated herein that HCE-EA inhibits NF-κB activation via the blockade of LPS-induced IкBα degradation and the subsequent nuclear translocation of the NF-κB p65 subunit.
In Z. sapae, an interchromosomal recombination may lead to the loss of HMR and the subsequent translocation of ZsHOs to the same chromosomes harboring ZsMTLα loci, giving rise to a chromosomal configuration different from that of Z. rouxii CBS 732T (Souciet et al. 2009).
TbAUK1 also interacts with two novel kinesin-like proteins TbKIN-A and TbKIN-B, both of which are required for the subsequent translocation of CPC from the chromosomes to the spindle midzone and to the unusual cleavage furrow, though they do not co-migrate with the CPC themselves in the procyclic form [11].
