Though subsequent studies did not confirm this result, the potential exists, as with any drugs, for toxic side effects in the future.
But in those cases as well, subsequent studies did not show as big a benefit as the initial studies.
The case of Avastin, in which subsequent studies did not show the same level of effect as the initial study, is one of only a few in which an approval has been revoked and the first one in which the manufacturer had requested a hearing to appeal the proposed revocation.
Some subsequent studies did not support a relationship between the Drymoreomys Eremoryzomys clade and the rest of clade D, but this is probably due to saturation of the phylogenetic signal in mitochondrial data.
However, subsequent studies did not detect actin-bundling activity of I-BAR in physiological conditions, but only weak and, possibly, non-specific actin-binding activity [11], [18].
However, subsequent studies did not produce a consensus on this point: one study reported a positive correlation between plasma viral load and the total HIV-specific, Env-, aNef-specificfiCD8+8+ T-cell frequency [7], while at least two others found no numerical relationship [8], [9].
However, subsequent studies did not confirm the association [ 45- 47].
A 1986 study suggested a positive association, but two subsequent studies did not support this association.
However, subsequent studies did not support the direct involvement of K279 of ProRS or K46 of YbaK in deacylation of aminoacyl-tRNAPro.
However, subsequent studies did not support the utility of MAPT as a predictor of the effect of taxanes [ 20, 21, 35, 36].
