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For non-syndromic CL ± P (cleft lip with or without cleft palate), the recurrence risk for a subsequent sibling is considered to be 3-5% [ 49, 51].
One would normally expect the risk of the same de novo mutation occurring in a subsequent sibling to be equivalent to zero or to be smaller than the de novo mutation rate baseline estimate of 1.1 × 10-8 to 1.2 × 10-8 [ 13, 31, 41, 42], which is the frequency of new single nucleotide variants per generation in humans.
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In families with an affected singleton child, risk was increased 9.2 (6.4 to 13 -fold in a subsequent full sibling and 3.0 (13 -fold.6)-fold in a half subsequent
18 Sub-samples (179 of 344 and 227 of 714) from the ITT-B and ITT-C, respectively, of An. gambiae sensu lato (members of this species complex are morphologically indistinguishable 24) were stored in tubes with desiccated silica for subsequent identification to sibling species level by polymerase chain reaction.
The first two - My Brother the Islamist and My Brother the Terrorist – focused on his white, middle-class sibling's conversion and subsequent radicalisation.
Despite the fact that, mainly through the iGEM channel, synthetic biology has been instrumental in the subsequent birth of its non-academic sibling, the two branches of constructive biology remain located at different sides of the institutional divide.
Subsequent HSCT was performed successfully, and the transplanted sibling is currently doing well, 4 years following transplantation.
A subsequent 'near-miss' SIDS episode occurred in another sibling who was noted to have a prolonged QT interval, as did a brother and parent.
The sibling was found to carry E146K and subsequent point mutation analysis on case 7s neonatal screening card was positive.
Some M2-derived lineages are represented by more than one plant, as sibling plants were sometimes sampled from segregating rows in subsequent generations.
At the end of the 2-wk baseline diet, one mouse from each sibling pair was assigned to one of two diets for subsequent investigation of gene × diet interactions.
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