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Slippage error creates a loop in one of the strands that gives rise to an insertion or a deletion in the subsequent replications, depending on the strand specificity (replicating or template strand) of loop formation.
Slippage creates a loop in one of strands that gives rise to an insertion or a deletion in the subsequent replications depending upon if the loop is formed in the replicating strand or in the template strand respectively.
The resulting gap can be filled by any base during subsequent replications.
Although studies with small samples tend to overestimate true effect sizes, overestimation may decrease with subsequent replications, a phenomenon termed the "Winner's Curse" (Button et al., 2013).
We observe that initial studies on a genetic marker tend to be substantially more biased than subsequent replications.
Our approach exploits this and allows us to investigate whether initial publications are more biased than subsequent replications, and whether early replications are biased against initial results.
Similar(52)
HR-mediated excision and subsequent replication of extra-chromosomal rDNA circles is an important cause of replicative aging in this organism.
But subsequent replication studies of this variant carried out in Italian Caucasian population failed to identify the association of rs548294 with migraine.
Random mutations occur in the RNA genome when reverse transcriptase converts the RNA into DNA; these mutations are not corrected and are passed on in subsequent replication cycles.
Given the large incidence rate and the lack of suitable surgical solutions for their regeneration or repair, characterization of their natural structure and subsequent replication through tissue engineering is important.
We show HNF4α is essential in vivo to sustain active viral transcription and subsequent replication.
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