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The subsequent parameters were obtained in the same way as described above in CoMFA.
From now on, subsequent parameters are selected one by one, and a new t-tuple is generated from the combination between each of the values (v k ) with each of the preexisting t-tuples (θ i ) in Θ (line 16).
The subsequent parameters were inspected using microscopic investigation: tumor diameter, number of nodules per section and the extent of necrosis and infiltration by mononuclear cells.
As more proper, the evaluation of subsequent parameters to be selected should be done based on the reestimated selected parameters values [ 17, 18], reducing the dependence on the initial parameters estimates.
Also, in the work of Alberton et al. [ 18], the reestimated values are used in the selection of subsequent parameters to be evaluated, but in such procedure the numerical efforts are significantly reduced using a binary search based algorithm.
Subsequent parameters were selected: all entries of NCBInr (National Center for Biotechnology Information, Rockville Pike, USA), tryptic digestion, up to one missed cleavage site was allowed and for global modifications carbamidomethyl at cysteines and oxidized methionine were given as variable modifications.
Similar(52)
Therefore, the column temperature was set at 6°C in the subsequent parameter development process.
This drastically limits the search space for subsequent parameter estimation methods.
Statistic based methods of evaluation of kinetics require implementation of a particular kinetic model on computer and subsequent parameter estimation.
The process of minimizing the objective function is starting with initial guess and generating subsequent parameter estimates that yield smaller values of the objective function.
In fact, correctly identifying the system order is essential to ensure that subsequent parameter estimation will yield a well-defined set of model coefficient estimates.
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