In these mice, recessive mutations in these 2 genes are associated with iris degeneration characterized by iris stromal atrophy and pigment dispersion with subsequent reduced outflow facility secondary to pigment and cell debris.
Altogether, it is likely that GLP-1R signalling and subsequent sympathetic outflow differ during obesity and lean conditions.
Moreover, after infection at higher MOI (250), DS progenitors showed larger invasomes, also displaying, in some cases, invasome and cell membrane rupture with subsequent bacteria outflow.
The ancient deltaic deposit we observe today was largely untouched by subsequent catastrophic outflows, and its surface has been only moderately reshaped by over 3 billion years of aeolian erosion.
Later scientific study of these anomalies supported the interpretation that the Moon had a complex history of heating, differentiation (sinking of denser materials and rising of lighter ones to form a deep mantle and overlying crust), and modification by impacts and subsequent huge outflows of lava.
Glucocorticoids increase IOP via deposition of extracellular matrix material in the juxtacanalicular tissue, leading to thickening of the trabecular meshwork beams, decreased intertrabecular spaces, and a subsequent increase in outflow resistance.
Vav2/Vav3-deficient mice should serve not only as a useful murine model of spontaneous glaucoma, but may also provide a valuable tool in understanding of the pathogenesis of glaucoma in humans, particularly the determinants of altered aqueous outflow and subsequent elevated intraocular pressure.
By expanding orbital volume, there is improved venous outflow with subsequent relief of congestion.
It is possible that, just after mydriasis, the flare may be increased by iris pigment liberation or by protein, but crowding in the angle and subsequent interruption through the outflow facility of the trabecular meshwork can explain the elevation of intraocular pressure.
